Table 2– Genes differentially expressed in nasal epithelial brushings from dust mite-allergic rhinitis patients versus healthy subjects (microarray analysis)

Probe set identifier	mRNA accession number	UniGene identifier	Gene	Gene product	Cytoband	log₂(signal)	log₂(allergic/healthy)	p-value
8065412	NM_001898	Hs.123114	*CST1*	Cystatin SN	20p11.21	9.65	7.15	4.95×10⁻¹²
7971077	NM_006475	Hs.136348/Hs.664318	*POSTN*	Periostin, osteoblast-specific factor	13q13.3	7.12	3.56	2.66×10⁻³
8083260	NM_001870	Hs.646	CPA3	Carboxypeptidase A3 (mast cell)	3q21–q25	6.17	2.51	5.20×10⁻⁵
7921690	NM_017625	Hs.50813	ITLN1	Intelectin 1 (galactofuranose binding)	1q22–q23.5	5.83	2.45	3.87×10⁻²
8065416	NM_001322	Hs.669305	CST2	Cystatin SA	20p11.21	7.97	1.87	1.06×10⁻³
8084657	NM_014375	Hs.81073	*FETUB*	Fetuin B	3q27	5.78	1.77	3.63×10⁻³
8021635	NM_002575	Hs.594481	*SERPINB2*	Serpin peptidase inhibitor, clade B (ovalbumin), member 2	18q21.3	9.20	1.64	6.97×10⁻³
8056222	NM_001935	Hs.368912	*DPP4*	Dipeptidyl-peptidase 4 (CD26)	2q24.3	6.44	1.56	6.18×10⁻³
7921900	NM_053282	Hs.350581	*SH2D1B*	SH2 domain-containing 1B	1q21	5.91	1.55	3.05×10⁻⁷
8036755	NM_001828	Hs.889	CLC	Charcot−Leyden crystal protein	19q13.1	4.57	1.50	2.73×10⁻²
7984001	NM_004751	Hs.194710	GCNT3	Glucosaminyl (N-acetyl) transferase 3, mucin type	15q21.3	8.73	1.39	8.15×10⁻⁵
8063761	NM_177980	Hs.54973	*CDH26*	Cadherin-like 26	20q13.2–q13.33	8.67	1.38	6.84×10⁻³
8089568	NM_138806	Hs.309158	CD200R1	CD200 receptor 1	3q13.2	8.90	1.35	3.90×10⁻⁵
8112668	NM_016591	Hs.272404	*GCNT4*	Glucosaminyl (N-acetyl) transferase 4, core 2 (β-1,6-N-acetylglucosaminyltransferase)	5q12	5.85	1.29	4.05×10⁻²
8070567	NM_003226	Hs.82961	TFF3	Trefoil factor 3 (intestinal)	21q22.3	9.86	1.26	2.11×10⁻²
7942135	NM_018043	Hs.503074	*TMEM16A*	Transmembrane protein 16A	11q13.3	7.41	1.23	6.48×10⁻³
8154233	NM_014143	Hs.521989	*CD274*	CD274 molecule	9p24	6.75	1.23	3.84×10⁻⁵
7957458	NM_006183	Hs.80962	NTS	Neurotensin	12q21	9.14	1.16	4.79×10⁻²
8023688	NM_002974	Hs.123035	*SERPINB4*	Serpin peptidase inhibitor, clade B (ovalbumin), member 4	18q21.3	8.67	1.15	3.40×10⁻³
8147132	NM_000067	Hs.155097	CA2	Carbonic anhydrase II	8q22	6.44	1.14	3.87×10⁻²
7909946	GENSCAN00000026059	NA	NA	NA	NA	6.01	1.14	1.05×10⁻²
8156134	NM_006180	Hs.494312//Hs.653428	NTRK2	Neurotrophic tyrosine kinase receptor, type 2	9q22.1	5.63	1.10	5.93×10⁻³
8102050	NM_178833	Hs.546482	NHEDC2	Na⁺/H⁺ exchanger domain-containing 2	4q24	6.02	1.02	6.84×10⁻³
8089851	NM_000187	Hs.368254	HGD	Homogentisate 1,2-dioxygenase (homogentisate oxidase)	3q13.33	5.71	-1.22	2.50×10⁻²

Genes were ranked according to decreasing log₂(allergic/healthy). Only genes with a log₂(ratio) >1 and a significant p-value (p<0.05) after a Benjamini–Hochberg correction for multiple tests were selected. Bold indicates genes induced in vitro with a value of log₂(ratio) >1 by both interleukin (IL)-4 and IL-13 in human nasal epithelial cells. A more detailed table is provided as online supplementary table E3. NA: not available.