Table 2– Prospective cohort: demographic, clinical, functional and radiographic characteristics at the time of diagnosis of 3-yr survivors and nonsurvivors
Subjects n3733
Age yrs66±467±9ns
BMI m·kg−229±427±30.0384
Time to diagnosis months20±1927±22ns
Smoking pack-yrs32±1634±22ns
Concomitant emphysema yes/no (%)9/28 (24)15/18 (45)0.0267
MRC dyspnoea score2.1±0.83.3±1.1<0.0001
6MWD m412±128319±1530.0184
6MWD % pred89±2766±270.0018
Desaturation at 6MWT# yes/no (%)19/16 (54)25/4 (86)0.0061
PA–a,O2 mmHg28±1336±170.0392
FVC % pred81±2168±230.0027
DL,CO % pred53±1737±170.0005
HRCT disease extent % of total lung volume33±1141±110.0098
BAL total cell count cells·mL−1417972±319004952444±6235050.0037
  • Data are presented as mean±sd, unless otherwise stated. BMI: body mass index; MRC: Medical Research Council; 6MWD: 6-min walking distance; % pred: % predicted; 6MWT: 6-min walking test; PA–a,O2: alveolar–arterial oxygen tension difference; FVC: forced vital capacity; DL,CO: diffusing capacity of the lung for carbon monoxide; CPI: composite physiologic index; HRCT: high-resolution computed tomography; BAL: bronchoalveolar lavage; ns: not significant. p-value: Chi-squared, unpaired t-test or Mann–Whitney U-test, where required. #: arterial oxygen saturation ≤88%.