Table 1– CXCR1 and CXCR2 tagging single-nucleotide polymorphisms (SNPs) and their association with lung function

SNP	Position	Location/function	Alleles	MAF FEV₁^# ≤70% pred		MAF FEV₁^# >70% pred		OR		p-value
*CXCR1*
rs2671222	-2668	Promoter	G/A	0.046		0.065		0.66		0.411
rs17838611	-2423	Promoter	G/A	0.027		0.007		3.92		0.028
rs16858841	-2329	Promoter	C/T	0.077		0.015		6.02		1.58×10⁻⁵
rs3138060	-1566	Intron	C/G	0.044		0.066		0.63		0.167
rs16858816	-143	Intron	C/T	0.066		0.016		4.61		2.31×10⁻⁴
rs16858811	92	Met/Arg	G/T	0.066		0.014		5.29		1.41×10⁻⁴
rs16858808	1003	Arg/Cys	C/T	0.052		0.016		3.55		0.003
*CXCR2*
rs3890158	-9203	Promoter	A/G		0.468		0.466		1.01		0.948
rs45493792	-9191	Promoter	-/T		0.364		0.370		0.94		0.791
rs3890157	-9185	Promoter	T/G		0.077		0.025		3.47		4.73×10⁻⁴
rs35231134	-9179	Promoter	-/T		0.510		0.498		1.05		0.822
rs4674258	-8909	Promoter	C/T		0.343		0.370		0.77		0.247
rs4674259	-8490	5′-UTR	A/G		0.382		0.354		1.34		0.741
rs17844697	-270	Intron	G/A		0.423		0.445		0.99		0.953
rs11574750	768	Val/Val	C/T		0.077		0.023		3.75		2.77×10⁻⁴
rs2230054	786	Leu/Leu	C/T		0.323		0.338		0.88		0.572
rs45606837	936	Leu/Leu	C/T		0.023		0.009		2.67		0.098
rs1126579	1209	3′-UTR	C/T		0.383		0.354		1.34		0.212
rs13306441	1420	3′-UTR	A/G		0.070		0.017		4.48		1.64×10⁻⁴
Rs17844765	1437	3′-UTR	C/T		0.007		0.006		1.20		0.844
Rs1126580	1441	3′-UTR	C/T		0.433		0.447		0.99		0.955

MAF: minor allele frequency; FEV₁: forced expiratory volume in 1 s; % pred: % predicted; UTR: untranslated region. Bold indicates significance after Bonferroni correction. ^#: longitudinal FEV₁, age-adjusted (20 yrs) [9].