IPAH | COPD | ILD | Sleep disorders and alveolar hypoventilation | |
Subjects n | 175 | 101 | 32 | 25 |
Age yrs | 55±16#,¶ | 69±10§ | 68±11§ | 61±10 |
Female | 67#,¶,+ | 37§ | 22§ | 44§ |
WHO III/IV | 67/20¶ | 67/25+ | 53/44+,§ | 67/8#,¶ |
ISWD m | 183±173#,¶ | 102±105§ | 97±97§ | 145±99 |
P̄ra mmHg | 11±6 | 10±5 | 8±7 | 11±7 |
P̄pa mmHg | 53±13#,¶,+ | 43±11§ | 39±9§ | 37±10§ |
CI L·min−1·m−2 | 2.3±0.8#,+ | 2.8±0.9§ | 2.5±0.6+ | 3.2±0.7¶,§ |
Ppcw mmHg | 10±3#,+ | 13±5+,§ | 11±8+ | 16±10#,¶,§ |
PVR dyn·s·cm−5 | 960±465#,¶,+ | 568±382§ | 560±321§ | 375±284§ |
Sv,O2 % | 61±9#,+ | 64±8§ | 63±10 | 69±8§ |
FEV1 % pred | 86±15#,¶,+ | 59±26§ | 66±25§ | 51±23§ |
FVC % pred | 97±18#,¶,+ | 85±25¶,+,§ | 66±25#,§ | 56±23#,§ |
TL,CO % pred | 52±21#,¶ | 32±16+,§ | 32±9+,§ | 57±19#,¶ |
Data are presented as mean±sd or %, unless otherwise stated. Idiopathic pulmonary arterial hypertension (IPAH) data are shown for comparison. COPD: chronic obstructive pulmonary disease; ILD: interstitial lung disease; WHO: World Health Organization functional class; ISWD: incremental shuttle walking distance; P̄ra: mean right atrial pressure; P̄pa: mean pulmonary artery pressure; CI: cardiac index; Ppcw: pulmonary capillary wedge pressure; PVR: pulmonary vascular resistance; Sv,O2: mixed venous oxygen saturation; FEV1: forced expiratory volume in 1 s; % pred: % predicted; FVC: forced vital capacity; TL,CO: transfer factor of the lung for carbon monoxide. #: p<0.05 in comparison to COPD; ¶: p<0.05 in comparison to ILD; +: p<0.05 in comparison to sleep/alveolar hypoventilation; §: p<0.05 in comparison to IPAH.