Table 1– Comparison of variables between decliners and non-decliners#
Non-declinersDeclinersp-value
Demographics
 Subjects n178
 Age yrs69 (53–78)72 (63–80)0.32
 Males/females n14/34/40.16
 Never-smokers6 (35)6 (75)0.10
Lung function tests
 FVC % pred70 (46–110)69 (44–114)0.60
DL,CO % pred35 (17–92)29 (24–44)0.33
 Resting Pa,O2 mmHg77 (53–91)76 (61–101)0.77
HRCT scores
 Alveolar score1.25 (0.33–2.00)1.67 (1.00–2.17)0.053
 Interstitial score2.00 (1.00–3.00)2.08 (1.83–2.50)0.49
Biomarkers
 SP-D ng·mL−1436 (110–1185)374 (250–836)0.74
 KL-6 U·mL−11895 (464–3857)1540 (687–2832)0.61
 CCL2 pg·mL−1375 (152–1099)308 (144–1172)0.45
 CCL18 ng·mL−1138 (64–395)118 (61–275)0.74
 Serum octreotide ng·mL−12.8 (<0.5–6.04)2.6 (<0.5–6.22)0.89
Uptake of octreotide in the lungs
111In-octreotide L/B5.32 (3.90–8.87)4.36 (3.49–5.81)0.11
  • Data are presented as mean (range) or n (%), unless otherwise stated. FVC: forced vital capacity; % pred: % predicted; DL,CO: diffusing capacity of the lung for carbon monoxide; Pa,O2: arterial oxygen tension; HRCT: high-resolution computed tomography; SP-D: surfactant protein-D; KL-6: Krebs von den Lungen-6; CCL: CC chemokine ligand; L/B: lung/background ratio. #: patients whose FVC decreased by ≥10% between two consecutive measurements (12-week interval) were termed as decliners and others as non-decliners.