Table 1– Summary of key inclusion and exclusion criteria
Inclusion criteriaExclusion criteria
Age >40 yrsKnown α1-antitrypsin deficiency
FEV1 >15% and <45% predEvidence of either clinically significant asthma, chronic bronchitis or bronchiectasis
TLC >100% predDL,CO <20% pred
RV >150% predPost-rehabilitation 6MWD <140 m
mMRC dyspnoea score ≥2Pneumothorax within previous 18 months
Pa,CO2 <55 mmHg, Pa,O2 >45 mmHg while breathing room airProcedures involving thoracotomy
Nonsmoking for >4 monthsLarge bullae (>1/3 volume of lobe)
Recent completion of pulmonary rehabilitationLeft ventricular ejection fraction ≤40%
BMI ≥15 kg·m−2 or ≤35 kg·m−2Stroke, unstable myocardial ischaemia or ICD
Pulmonary hypertension (peak systolic Ppa ≥45 mmHg or mean Ppa ≥35 mmHg
Previous bronchoscopic LVR
  • FEV1: forced expiratory volume in 1 s; % pred: % predicted; TLC: total lung capacity; RV: residual volume; mMRC: modified Medical Research Council; Pa,CO2: arterial carbon dioxide tension; Pa,O2: arterial oxygen tension; BMI: body mass index; DL,CO: diffusing capacity of the lung for carbon dioxide; 6MWD: 6-min walking distance; ICD: implantable cardioverter-defibrillator; Ppa: pumonary arterial pressure; LVR: lung volume reduction.