Table 4– Prospective and retrospective cohorts: 3-yr survival Cox proportional hazard analysis of variables at the time of diagnosis
VariableHazard ratio (95% CI)p-value
Prospective cohort#
 MRC dyspnoea score >36.77 (2.37–19.41)0.0005
 6MWD <72% pred3.27 (1.25–8.82)0.0162
 CPI >415.36 (1.50–34.15)0.0071
Retrospective cohort
 6MWD <72% pred5.43 (1.35–36.17)0.016
 CPI >414.20 (1.05–27.93)0.042

  • MRC: Medical Research Council; 6MWD: 6-min walking distance; % pred: % predicted; CPI: composite physiologic index. #: p-value of the model <0.0001; : p-value of the model 0.0053.