Table 1– Baseline characteristics of the patients
VariableEBV therapyControlp-value
Patients n11160
Demographic characteristics
 Age yrs59.7±7.960.4±7.40.576
 Males75 (68)48 (80)0.084
 White#111 (100)59 (98)
 BMI kg·m−222.9±3.823.8±3.80.168
 Smoking history
  Ever smoked109 (98)60 (100)
  Yrs of smoking33.7±8.934.3±8.10.700
  Pack-yrs76.9±6.147.1±19.60.413
 Receiving oxygen therapy80 (72)29 (48)0.002
Arterial blood gas
Pa,O2 mmHg69.3±10.669.7±11.50.814
Pa,CO2 mmHg38.9±4.638.6±5.30.691
Lung function
 FEV1 L0.91±0.290.94±0.300.529
 FEV1 % pred29±830±80.451
 FVC L2.50±0.732.67±0.860.158
 FVC % pred61±1365±170.158
DL,CO mL·min−1·mmHg−19.77±3.839.67±3.510.861
 RV L5.02±1.164.98±1.070.814
 RV % pred240±51240±470.948
 TLC L7.82±1.477.94±1.180.597
 TLC % pred127±15129±140.117
Exercise performance, quality of life
 Cycle ergometry peak workload W46.9±20.352.2±23.40.117
 6MWD m341±108360±1170.396
 SGRQ59±1356±180.150
  • Data are presented as mean±sd or n (%), unless otherwise stated. EBV: endobronchial valve; BMI: body mass index; Pa,O2: arterial oxygen tension; Pa,CO2: arterial carbon dioxide tension; FEV1: forced expiratory volume in 1 s; % pred: % predicted; FVC: forced vital capacity; DL,CO: diffusing capacity of the lung for carbon monoxide; RV: residual volume; TLC: total lung capacity; 6MWD: 6-min walk distance; SGRQ: St George’s Respiratory Questionnaire. #: race was self-reported; : measurements were performed while the patient was breathing ambient air.