TY - JOUR T1 - Antibiotic therapy affects functional behaviour in cystic fibrosis blood mononuclear cells JF - European Respiratory Journal JO - Eur Respir J SP - 558 LP - 561 DO - 10.1183/09031936.00230214 VL - 46 IS - 2 AU - Lorenzo Guerra AU - Maria Favia AU - Stefano Castellani AU - Giovanna Barbuti AU - Pasqualina Montemurro AU - Anna Diana AU - Teresa Santostasi AU - Angela M. Polizzi AU - Maria A. Mariggiò AU - Stephan J. Reshkin AU - Antonio Manca AU - Valeria Casavola AU - Massimo Conese Y1 - 2015/08/01 UR - http://erj.ersjournals.com/content/46/2/558.abstract N2 - Cystic fibrosis (CF) is the most common life-shortening genetic disorder in the Caucasian population and is due to mutations at the CF transmembrane conductance regulator (CFTR) gene leading to dysfunction of the protein, which normally acts as a chloride channel. This basic defect is associated with a progressive and lethal lung disease [1]. Opportunistic respiratory infections are common in CF patients' lungs, making antibiotics an important part of the regular care.Antibiotic therapy indirectly restores adequate levels of functional F508delCFTR in CF lymphomonocytes http://ow.ly/Ncydg ER -