RT Journal Article
SR Electronic
T1 BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1403
OP 1414
DO 10.1183/09031936.00097214
VO 45
IS 5
A1 Sébastien Couraud
A1 Pierre-Jean Souquet
A1 Christophe Paris
A1 Pascal Dô
A1 Hélène Doubre
A1 Eric Pichon
A1 Adrien Dixmier
A1 Isabelle Monnet
A1 Bénédicte Etienne-Mastroianni
A1 Michel Vincent
A1 Jean Trédaniel
A1 Marielle Perrichon
A1 Pascal Foucher
A1 Bruno Coudert
A1 Denis Moro-Sibilot
A1 Eric Dansin
A1 Stéphanie Labonne
A1 Pascale Missy
A1 Franck Morin
A1 Hélène Blanché
A1 Gérard Zalcman
YR 2015
UL http://erj.ersjournals.com/content/45/5/1403.abstract
AB Lung cancer in never-smokers (LCINS) (fewer than 100 cigarettes in lifetime) is considered as a distinct entity and harbours an original molecular profile. However, the epidemiological and molecular features of LCINS in Europe remain poorly understood. All consecutive newly diagnosed LCINS patients were included in this prospective observational study by 75 participating centres during a 14-month period. Each patient completed a detailed questionnaire about risk factor exposure. Biomarker and pathological analyses were also collected. We report the main descriptive overall results with a focus on sex differences. 384 patients were included: 65 men and 319 women. 66% had been exposed to passive smoking (significantly higher among women). Definite exposure to main occupational carcinogens was significantly higher in men (35% versus 8% in women). A targetable molecular alteration was found in 73% of patients (without any significant sex difference): EGFR in 51%, ALK in 8%, KRAS in 6%, HER2 in 3%, BRAF in 3%, PI3KCA in less than 1%, and multiple in 2%. We present the largest and most comprehensive LCINS analysis in a European population. Physicians should track occupational exposure in men (35%), and a somatic molecular alteration in both sexes (73%). Occupational exposure and targetable mutation should be tracked in lung cancer of European never-smokers. http://ow.ly/FB2WS