PT  - JOURNAL ARTICLE
AU  - Couraud, Sébastien
AU  - Souquet, Pierre-Jean
AU  - Paris, Christophe
AU  - Dô, Pascal
AU  - Doubre, Hélène
AU  - Pichon, Eric
AU  - Dixmier, Adrien
AU  - Monnet, Isabelle
AU  - Etienne-Mastroianni, Bénédicte
AU  - Vincent, Michel
AU  - Trédaniel, Jean
AU  - Perrichon, Marielle
AU  - Foucher, Pascal
AU  - Coudert, Bruno
AU  - Moro-Sibilot, Denis
AU  - Dansin, Eric
AU  - Labonne, Stéphanie
AU  - Missy, Pascale
AU  - Morin, Franck
AU  - Blanché, Hélène
AU  - Zalcman, Gérard
TI  - BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers
AID  - 10.1183/09031936.00097214
DP  - 2015 May 01
TA  - European Respiratory Journal
PG  - 1403--1414
VI  - 45
IP  - 5
4099  - http://erj.ersjournals.com/content/45/5/1403.short
4100  - http://erj.ersjournals.com/content/45/5/1403.full
SO  - Eur Respir J2015 May 01; 45
AB  - Lung cancer in never-smokers (LCINS) (fewer than 100 cigarettes in lifetime) is considered as a distinct entity and harbours an original molecular profile. However, the epidemiological and molecular features of LCINS in Europe remain poorly understood. All consecutive newly diagnosed LCINS patients were included in this prospective observational study by 75 participating centres during a 14-month period. Each patient completed a detailed questionnaire about risk factor exposure. Biomarker and pathological analyses were also collected. We report the main descriptive overall results with a focus on sex differences. 384 patients were included: 65 men and 319 women. 66% had been exposed to passive smoking (significantly higher among women). Definite exposure to main occupational carcinogens was significantly higher in men (35% versus 8% in women). A targetable molecular alteration was found in 73% of patients (without any significant sex difference): EGFR in 51%, ALK in 8%, KRAS in 6%, HER2 in 3%, BRAF in 3%, PI3KCA in less than 1%, and multiple in 2%. We present the largest and most comprehensive LCINS analysis in a European population. Physicians should track occupational exposure in men (35%), and a somatic molecular alteration in both sexes (73%). Occupational exposure and targetable mutation should be tracked in lung cancer of European never-smokers. http://ow.ly/FB2WS