PT  - JOURNAL ARTICLE
AU  - Silke Meiners
AU  - Oliver Eickelberg
AU  - Melanie Königshoff
TI  - Hallmarks of the ageing lung
AID  - 10.1183/09031936.00186914
DP  - 2015 Mar 01
TA  - European Respiratory Journal
PG  - 807--827
VI  - 45
IP  - 3
4099  - http://erj.ersjournals.com/content/45/3/807.short
4100  - http://erj.ersjournals.com/content/45/3/807.full
SO  - Eur Respir J2015 Mar 01; 45
AB  - Ageing is the main risk factor for major non-communicable chronic lung diseases, including chronic obstructive pulmonary disease, most forms of lung cancer and idiopathic pulmonary fibrosis. While the prevalence of these diseases continually increases with age, their respective incidence peaks at different times during the lifespan, suggesting specific effects of ageing on the onset and/or pathogenesis of chronic obstructive pulmonary disease, lung cancer and idiopathic pulmonary fibrosis. Recently, the nine hallmarks of ageing have been defined as cell-autonomous and non-autonomous pathways involved in ageing. Here, we review the available evidence for the involvement of each of these hallmarks in the pathogenesis of chronic obstructive pulmonary disease, lung cancer, or idiopathic pulmonary fibrosis. Importantly, we propose an additional hallmark, “dysregulation of the extracellular matrix”, which we argue acts as a crucial modifier of cell-autonomous changes and functions, and as a key feature of the above-mentioned lung diseases. Hallmarks of ageing are selecting factors for the pathogenesis of COPD, lung cancer and IPF http://ow.ly/HeM2n