RT Journal Article
SR Electronic
T1 A contemporary survival analysis of individuals with cystic fibrosis: a cohort study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 670
OP 679
DO 10.1183/09031936.00119714
VO 45
IS 3
A1 Anne L. Stephenson
A1 Melissa Tom
A1 Yves Berthiaume
A1 Lianne G. Singer
A1 Shawn D. Aaron
A1 G.A. Whitmore
A1 Sanja Stanojevic
YR 2015
UL http://erj.ersjournals.com/content/45/3/670.abstract
AB Previously established predictors of survival may no longer apply in the current era of cystic fibrosis (CF) care. Our objective was to identify risk factors associated with survival in a contemporary CF population. We used the Canadian CF Registry, a population-based cohort, to calculate median age of survival and summarise patient characteristics from 1990 to 2012. Clinical, demographic and geographical factors, and survival were estimated for a contemporary cohort (2000–2012) using Cox proportional hazards models. There were 5787 individuals in the registry between 1990 and 2012. Median survival age increased from 31.9 years (95% CI 28.3–35.2 years) in 1990 to 49.7 years (95% CI 46.1–52.2 years) in the most current 5-year window ending in 2012. Median forced expiratory volume in 1 s improved (p=0.04) and fewer subjects were malnourished (p<0.001) over time. Malnourished patients (hazard ratio (HR) 2.1, 95% CI 1.6–2.8), those with multiple exacerbations (HR 4.5, 95% CI 3.2–6.4) and women with CF-related diabetes (HR 1.8, 95% CI 1.2–2.7) were at increased risk of death. Life expectancy in Canadians with CF is increasing. Modifiable risk factors such as malnutrition and pulmonary exacerbations are associated with an increased risk of death. The sex gap in CF survival may be explained by an increased hazard for death in women with CF-related diabetes. Malnutrition and pulmonary exacerbations increase the risk of death in CF but survival in CF has increased over time http://ow.ly/CUqA9