RT Journal Article
SR Electronic
T1 Late-breaking abstract: The level of markers of endothelial dysfunction in men with chronic obstructive pulmonary disease and osteopenic syndrome
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4719
VO 44
IS Suppl 58
A1 Evgenia Kochetkova
A1 Ludmila Ugay
A1 Yulia Maistrovskaya
A1 Vera Nevzorova
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P4719.abstract
AB Aim: to investigate the role of markers of endothelial dysfunction in formation of osteoporosis in COPD.Materials : Soluble E-selectin, endotheline 1 (ET-1), vitamin D, VEGF, MMP-9, vascular cell adhesion molecule (VCAM-1), osteoprotegerin (OPG), the receptor activator of nuclear factor-kB ligand (RANKL) and bone markers were determined in 73 COPD men. BMD was measured by DEXA at the lumbar spine (LS) and left femur neck (FN).Results: bone formation markers (procollagen type 1 amino-terminal propeptide P1NP), N-terminal midmolecule fragment osteocalcin (N-MID OC), bone specific alkaline phosphatase were lower in COPD than in controls. Type 1 collagen C-telopeptide (CTx-resorption marker) was higher in lung group and related to FN and had a relationship with P1NP. E-selectin, ET-1, VEGF, RANKL, MMP-9, VCAM-1 were higher; Vitamin D, OPG were low in lung groupe. Compared to the lung group with osteopenia, E-selectin, ET-1, MMP-9 and VEGF were the highest in COPD with osteoporosis. There was positive correlation between vitamin D, OPG and negative between MMP-9 and BMD in FN and LS ; inverse correlation between ET-1, VEGF in L2-L4; negative correlation of VCAM-1 with BMD in FN. OPG was correlated with N-MID OC, RANKL in lung patients. No correlations were found between VCAM-1 and markers of bone metabolism. ET-1, MMP-9 and VEGF positively correlated with parameters of bone resorption and negatively associated with P1NP and N-MID OC.Conclusion: we observed a significant association between parameters of bone metabolism and endothelial dysfunction markers in COPD, which suggests possible role of endothelial dysfunction in the increasing of bone loss in COPD.