PT - JOURNAL ARTICLE AU - Rodrigo, Chamira AU - Bewick, Thomas AU - Sheppard, Carmen AU - Greenwood, Sonia AU - Mckeever, Tricia M. AU - Trotter, Caroline L. AU - Slack, Mary AU - George, Robert AU - Lim, Wei Shen TI - Impact of infant 13-valent pneumococcal conjugate vaccine on serotypes in adult pneumonia AID - 10.1183/09031936.00183614 DP - 2015 Jun 01 TA - European Respiratory Journal PG - 1632--1641 VI - 45 IP - 6 4099 - http://erj.ersjournals.com/content/45/6/1632.short 4100 - http://erj.ersjournals.com/content/45/6/1632.full SO - Eur Respir J2015 Jun 01; 45 AB - Infant 13-valent pneumococcal conjugate vaccination (PCV13) was introduced to the UK in 2010. Its impact on serotypes implicated in adult non-bacteraemic pneumococcal pneumonia is not known. Beginning in 2008, a 5-year prospective cohort study of adults admitted to hospital with community-acquired pneumonia (CAP) was conducted. Pneumococcal serotype was established using a validated multiplex immunoassay (Bio-Plex; Bio-Rad, Hercules, CA, USA). The overall incidence for hospitalised CAP and pneumococcal CAP was 79.9 (95% CI 76.6–83.3) and 23.4 (95% CI 21.6–25.3) per 100 000 population, respectively. A decline in CAP (incidence rate ratio (IRR) per year 0.96, 95% CI 0.94–0.99; p=0.016) and pneumococcal CAP (IRR per year 0.84, 95% CI 0.80–0.89; p<0.001) was observed over the 5-year period of the study. Between the pre- and post-PCV13 periods of the study, the incidence of CAP due to serotypes included in the PCV7 declined by 88% (IRR 0.12, 95% CI 0.08–0.20; p<0.001), and CAP due to the additional 6 serotypes in PCV13 declined by 30% (IRR 0.70, 95% CI 0.51–0.96; p=0.024). Incidence of adult pneumococcal pneumonia declined over the last 5 years, with serotypes included in PCV13 declining post-PCV13 introduction, indicating early herd protection effects from PCV13 infant vaccination on adult non-bacteraemic disease. These effects may accrue over the coming years with implications for national pneumococcal vaccination policies in adults. This is the first study to indicate herd protection from infant PCV13 on adult non-bacteraemic pneumococcal pneumonia http://ow.ly/HHP75