PT  - JOURNAL ARTICLE
AU  - Keith M. Allan
AU  - Nanda Prabhu
AU  - Leone C.A. Craig
AU  - Geraldine McNeill
AU  - Bradley Kirby
AU  - James McLay
AU  - Peter J. Helms
AU  - Jon G. Ayres
AU  - Anthony Seaton
AU  - Stephen W. Turner
AU  - Graham Devereux
TI  - Maternal vitamin D and E intakes during pregnancy are associated with asthma in children
AID  - 10.1183/09031936.00102214
DP  - 2015 Apr 01
TA  - European Respiratory Journal
PG  - 1027--1036
VI  - 45
IP  - 4
4099  - http://erj.ersjournals.com/content/45/4/1027.short
4100  - http://erj.ersjournals.com/content/45/4/1027.full
SO  - Eur Respir J2015 Apr 01; 45
AB  - Are maternal vitamin D and E intakes during pregnancy associated with asthma in 10-year-old children?In a longitudinal study of 1924 children born to women recruited during pregnancy, maternal vitamin D intake during pregnancy was assessed by the Food Frequency Questionnaire (FFQ) and vitamin E by FFQ and plasma α-tocopherol; respiratory questionnaires were completed for the 10-year-old children. Their treatment for asthma was also ascertained using administrative data. Longitudinal analyses included data collected at 1, 2, 5 and 10 years.Symptom data were available for 934 (49%) children and use of asthma medication for 1748 (91%). In the children maternal vitamin D intake during pregnancy was negatively associated with doctor-diagnosed asthma at 10 years of age (OR per intake quintile 0.86, 95% CI 0.74–0.99) and over the first 10 years (hazard ratio 0.90, 95% CI 0.81–1.00). Maternal plasma α-tocopherol at 11 weeks gestation was negatively associated with children receiving asthma treatment (OR per standard deviation increase 0.52, 95% CI 0.31–0.87). Maternal vitamin E intake was negatively associated with doctor-diagnosed asthma (OR 0.89, 95% CI 0.81–0.99) in the first 10 years.Low maternal vitamin D and E intakes during pregnancy are associated with increased risk of children developing asthma in the first 10 years of life. These associations may have significant public health implications.Children born to women with low vitamin D and E intakes during pregnancy are more likely to develop asthma by age 10 http://ow.ly/CmDo8