TY - JOUR T1 - Club cells and CC16: another “smoking gun”? (With potential bullets against COPD) JF - European Respiratory Journal JO - Eur Respir J SP - 1519 LP - 1520 DO - 10.1183/09031936.00010515 VL - 45 IS - 6 AU - Lucie Knabe AU - Aurélie Fort AU - Pascal Chanez AU - Arnaud Bourdin Y1 - 2015/06/01 UR - http://erj.ersjournals.com/content/45/6/1519.abstract N2 - Chronic obstructive pulmonary disease (COPD) remains a challenge for clinicians and scientists, as no currently available treatment can significantly change the natural history of the disease. Accelerated lung function decline and recurrent episodes of exacerbations are thought to play critical roles in precipitating patients towards comorbid conditions, long-term oxygen supplementation dependency, and finally death. Currently, the underlying paradigm counterbalances alveolar wall destruction with peribronchiolar fibrosis, the latter being hypothesised to precede the former [1]. Although small airways are now largely recognised as the critical zone of disease initiation and progression [2], very few histological and biological properties specific to this compartment in humans have been highlighted to explain this phenomenon. Greater susceptibility of knockout CC16 mice to cigarette smoking gives insight regarding a potential player in COPD http://ow.ly/KhCMa ER -