TY - JOUR T1 - High prevalence of sleep disordered breathing (SDB) in patients with systemic AL amyloidosis JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P4928 AU - Shameem Mahmood AU - Leena George AU - Milind Sovani AU - Peter Smith AU - Philip Hawkins AU - Sajitha Sachchithanantham AU - Thirusha Lane AU - Lisa Rannigan AU - Darren Foard AU - Rabya Sayed AU - Ketna Patel AU - Marianna Fontana AU - Carol Whelan AU - Helen Lachmann AU - Julian D. Gillmore AU - Ashutosh Wechalekar Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P4928.abstract N2 - Background: Patients with systemic amyloidosis with Oropharyngeal soft tissue abnormalities and/or heart failure are likely to have increased prevalence of sleep disordered breathing (SDB) and obstructive sleep apnoea (OSA) yet little data exist on this topic.Aims: To explore the incidence of SDB in patients diagnosed with cardiac and or soft tissue involvement with macroglossia,Methods: Between July 2013 and February 2014 Fifty three patients with either cardiac or macroglossia with clinical suspicion of SDB completed the Epworth Sleepiness Score (ESS) and STOP BANG questionnaire for OSA and underwent overnight Pulse Oximetry in addition to the standard protocol at the UK National Amyloidosis Centre.Results: Data for 46 patients analysed: (Median Age 66, 58% male, median BMI 26). Twenty three patients had macroglossia and 30 had cardiac involvement. Fifteen,11, and 22 patients reported snoring, witnessed apnoeas and had neck circumference > 40cm respectively. 21 and 8 patients had STOP Bang score ≥3, ESS score more than 10 respectively. High risk of OSA was present in 20 (43%) by STOP BANG questionnaire score of ≥ 3. Overnight oximetry was abnormal in 32 (68%) patients. 32, 18, 13 patients had 4% Oxygen Desaturation Index (ODI) more than 5, 10, 15/hour respectively.Conclusion: There is a high prevalence of SDB in Amyloidosis. Most patients are tired but not sleepy. There was no difference in any parameters between patients with macroglossia and cardiac involvement. STOP BANG questionnaire likely to miss out those with central SDB due to heart failure. Sleep Polygraphy and longitudinal studies are needed to characterise this further and to assess effects on cardiac mortality. ER -