RT Journal Article
SR Electronic
T1 The distribution of phenotypes in a population of severe COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1938
VO 44
IS Suppl 58
A1 Vladimir Koblizek
A1 Jaromir Zatloukal
A1 Marek Plutinsky
A1 Petr Safranek
A1 Barbora Novotna
A1 Eva Kocova
A1 Magda Vytrisalova
A1 Katerina Neumannova
A1 Alena Vlachova
A1 Miloslav Marel
A1 Marie Majerciakova
A1 Pavlina Musilova
A1 Blanka Snelerova
A1 Patrice Popelkova
A1 Rudolf Praus
A1 Michal Kopecky
A1 Ladislava Pavlikova
A1 Tomas Dvorak
A1 Lucie Heribanova
A1 Tomas Vencalek
A1 Karel Hejduk
A1 Jiri Jarkovsky
A1 Jan Svancara
A1 Miloslav Hronek
A1 Miroslav Kovarik
A1 Norbert Pauk
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/1938.abstract
AB Background: COPD is a heterogeneous syndrome. Detailed information on the incidence of COPD phenotypes in the population is currently unavailable.Aim: The analysis of the COPD population with severe bronchial obstruction in relation to clinically apparent phenotypes.Methods: Non-interventional observational prospective Czech Multicentre Research Database of COPD focusing on the collection and data analysis of COPD population with post-BD FEV1 ≤ 60%. More at ClinicalTrials.gov, NCT01923051.Results: In the first six months we enrolled 190 consecutive patients (67,0 years, 77,4% males, 8,4% non-smokers) with post-BD FEV1 42%. All categories were included (A 5,8%, B 20%, C 11%, D 63,2%). Clinically apparent phenotypes were present in all patients (more than one phenotype in 44,2% subjects). In addition to the bronchitic and emphysematic phenotypes, the database identified frequent exacerbators in 23,2%, asthma+COPD overlap in 11,1%, bronchiectasis+COPD overlap in 2,1% and pulmonary cachexia in 8,9% of severe COPD subjects. Some phenotypes were significantly associated with the presence of particular comorbidities (more cardiac comorbidities and upper airway impairment in the bronchitic phenotype, more osteoporosis in the emphysematous phenotype) and clinical parameters (lower KCO and higher oxygen desaturation during 6-minute walking test in emphysematous phenotype). Mucus predominance in CAT was significantly associated with bronchitic phenotype.Conclusion: Preliminary analysis of baseline data demonstrates the variability of clinical parameters in patients with severe COPD. The effectiveness of a phenotype oriented approach to patients with COPD will be assessed by prospective follow-up of our patients.