RT Journal Article
SR Electronic
T1 Evaluation of vitamin D in bronchial asthma and the effect of vitamin D supplementation on asthma severity and control: A randomised control trial
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4049
VO 44
IS Suppl 58
A1 Menon, Balakrishnan
A1 Nima, Gaki
A1 Dogra, Vikas
A1 Mittal, Ankit
A1 Kaur, Charanjeet
A1 Mittal, Upasana
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P4049.abstract
AB BackgroundVitamin D is increasingly being linked to asthma. Higher Vitamin D levels are associated with decreased airway hyperresponsiveness and decreased inflammatory markers. Low levels of vitamin D may be associated with poor asthma control and increased severity.AimsTo evaluate Vitamin D levels in asthma and the effect of Vitamin D supplementation on severity and control of asthma.MethodsForty two subjects of asthma were recruited. The Asthma Control Test (ACT) score was calculated. Vitamin D was estimated by enhanced chemiluminiscence method. Subjects were randomly assigned to the Study group and Control group. The study group received standard therapy along with oral vitamin D (1000 IU) for 8 weeks. Control group received standard medications only. ACT scores and Vitamin D levels were reassessed at the end of study.ResultsThe mean Vitamin D in study group was 18.16 ± 5.32ng/ml which improved to 27.16 ± 7.61ng/ml after supplementation. The value in control group was 18.79 ± 6.07 at the start and 19.14 ± 5.81 at end of study. The difference was highly significant (p<0.01).The mean ACT score in study group was 16.62 ± 3.18 which improved to 22.08 ± 1.17 after treatment. The difference was highly significant (p<0.001). In the control group it was 17.57 ± 6.86 at the start and 19.78 ± 2.39 at the end of study (p<0.05). Those with lower vitamin D levels had lower ACT scores and vitamin D supplementation resulted in significant improvement in ACT scores (p<0.05).ConclusionVitamin D levels were low in patients of asthma. There was highly significant improvement in asthma control and severity after supplementation with Vitamin D.