%0 Journal Article %A Helena Azcuna %A Cristobal Esteban %A Inmaculada Arostegi %A Javier Moraza %A Myriam Aburto %A Amaia Aramburu %A Mikel Egurrola %T Mortality predictors in stable COPD %D 2014 %J European Respiratory Journal %P P3613 %V 44 %N Suppl 58 %X OBJECTIVE: To assess the general and respiratory mortality in a stable COPD patient cohort.MATERIALS AND METHODS: From January 2003 to January 2004 543 stable COPD patients were selected with FEV1 80% and FEV1/FVC 70% spirometric criteria. They were controlled in our consuts for more than 6 months and stayed stable at least he last 6 weeks. They were followed up for 5 years without any intervention from the resercher.RESULTS: From 543 patients included 96% were men with mean age of 68 years, BMI 28.3, Charlson index 2.4+/-1.4 and FEV1 55.0+/-13.3. 48,6% of patients refered grade 2 in MRC scale. In the multivariate analysis following variables were significant: previous hopitalization, Charlson index, dyspnea by Medical Research Council (MRC) scale, self-refered physical activity, cardiovascular diseases, FEV1 (GOLD scale), DLCO, age, body mass index (BMI), hand strenth, quadriceps strenth and walking test in 6 minutes. By using logistic regression model categorizated variable were analyzed. Charlson index, age, DLCO and physical activity were demonstrated as independent variables of general mortality AUC 0,82 (CI 95% 0,79-0,86). Bootstrap validation: AUC 0,92 (CI 95% 0,88-0,95). Data were also considered for respiratory mortality with the same statistic model, with evidence of statistical significant differences in DLCO, FEV1, age and walking test. AUC 0,91 (CI ,87-0,94). Bootstrap validation AUC 0,916 (CI 95% 0,88-0,95).CONCLUSION: Charlson Index, DLCO, age and physical activity were mortality predictors in our stable COPD patients cohort. DLCO, FEV1, age and walking test were respiratory mortality predictors. %U