RT Journal Article
SR Electronic
T1 Negative correlation between respiratory drive and SNIP in amyotrophic lateral sclerosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2147
VO 44
IS Suppl 58
A1 Vitaliano Quaranta
A1 Lorenzo Marra
A1 Pierluigi Carratù
A1 Vito Falcone
A1 Anna Cassano
A1 Silvano Dragonieri
A1 Onofrio Resta
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2147.abstract
AB Respiratory Drive is a neurogenic stimulus for physiologic respiratory activity. It has been shown increased or decreased in different pathological conditions. Aim of this study was to evaluate the respiratory drive in Amyotrophic Lateral Sclerosis (ALS), compared to a healthy population, and to examine possible correlations with arterial blood gas (ABG), or with functional parameters.We enrolled twenty-three (17 males) consecutive patients affected by ALS, and eighteen (13 males) healthy controls. Both groups were compared with rergard to anthropometrics, ABG, functional parameters, and respiratory drive [mouth occlusion pressure (P0.1), VT/Ti, Ti/Ttot].In patients affected by ALS, we found an increased level of respiratory drive parameters compared to the control group (P0.1 1.64±1.01 vs. 1.21±0.32; p=0.05. VT/Ti 0.46±0.15 vs. 0.38±0.09; p=0.039). SNIP values higher than 20 cmH2O inversely correlated with mouth occlusion pressure (P0.1) (p=0.016; r2=-0.328) and with VT/Ti (p=0.044, r2=-0.243). It has been also observed a correlation tendency between lower FVC values and increased respiratory drive (p=0.08).In conclusion, in ALS patients with SNIP higher than 20 cmH2O, we found an augmented respiratory drive activity compared to healthy controls, probably due to a significative reduction of muscular actvity.