PT  - JOURNAL ARTICLE
AU  - Daniel López-Padilla
AU  - Ricardo García-Luján
AU  - Perla Valenzuela Reyes
AU  - Eduardo De Miguel Poch
TI  - Diagnostic yield of EBUS-TBNA in mediastinal lymphadenopathy of extrapulmonary malignancies
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P2782
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P2782.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P2782.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - IntroductionEndobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has not been widely described as an accurate diagnostic procedure in mediastinal lymphadenopathy of extrapulmonary malignancies. The aim of this study was to estimate the diagnostic yield of EBUS-TBNA in this scenario.MethodsDescriptive study of 47 consecutive patients with extrapulmonary malignancies for mediastinal lymphadenopathy study, from January 2010 to July 2013. Malignancy findings were not confirmed since a specificity of 100% was assumed. Negative results were confirmed with mediastinoscopy or at least 6 months of clinical and radiological follow up. Non representative tissue samples were excluded.ResultsEBUS-TBNA found malignancy in 24 out of 47 (51%) patients. Malignancy was ruled out in 18 cases (38%) and mediastinoscopy confirmed these results in 5 patients. There were 5 false negative results (11%), confirmed through mediastinoscopy or clinical and radiological progression. Sensitivity, negative predictive value and accuracy of EBUS-TBNA were 83% (CI95% 64 – 94), 78% (CI95% 56 – 92) and 89%, respectively. Immunohistochemical staining was performed in 18 cases (38%). Histological findings are presented in Table 1.View this table:Table 1. Histological findings.ConclusionsEBUS-TBNA has a reliable diagnostic yield in extrathoracic malignancies with mediastinal lymphadenophaty. Head and neck, breast and kidney represented half of metastasis origin in this study.