RT Journal Article
SR Electronic
T1 Drug resistant tuberculosis in urban hotspot
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2610
VO 44
IS Suppl 58
A1 Jayalakshmi, T.K.
A1 Iyer, Aparna
A1 Nair, Girija
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2610.abstract
AB Background:Poverty and overcrowding in urban slums creates hot spots for initial drug resistant tuberculosis. One such area is the M (east) ward in Mumbai, India.Aim:1. To identify factors for drug resistant TB in urban slums2. Study resistance patterns to anti-TB drugsMethod: Retrospective analysis of records at a tertiary care hospital in Navi Mumbai was done. Patients from M (east) ward in Mumbai were included. Multidrug resistant (MDR) and extensively drug resistant (XDR) TB were diagnosed by analysis of sputum/relevant samples by Line probe assay, liquid culture and sensitivity.Results:38 patients (23 men,15 women), had drug resistant TB. 33(84%) had MDR, 5(16%) XDR TB. No HIV/diabetes.Initial drug resistance - MDR-5/33 (15%). XDR-1/5(20%).Contact history- 6/38 (15%) cases.Causes identified in each group-View this table:Causes of drug resistanceDrug resistance:High degree of initial drug resistance to quinolones found in MDR(67%) patients.Conclusion: 1.50% of patients in urban slum area with drug resistant TB had no identified cause.2. High prevalence of drug resistance in the community contributes to this .3. 67% MDR isolates resistant to quinolones.4. Drug susceptibility at the outset will be useful in such areas.