RT Journal Article
SR Electronic
T1 Retrospective investigation of patients positive for glycopeptidolipid-core antibody to mycobacterium avium complex pulmonary disease
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2593
VO 44
IS Suppl 58
A1 Yasunari Oki
A1 Tukasa Ohnishi
A1 Sojiro Kusumoto
A1 Yasunori Murata
A1 Shin Ohta
A1 Mayumi Yamamoto
A1 Yoshio Watanabe
A1 Shintaro Suzuki
A1 Hiroo Ishida
A1 Takao Shirai
A1 Akihiko Tanaka
A1 Takuya Yokoe
A1 Hironori Sagara
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2593.abstract
AB Background: In recent years, the incidence of Mycobacterium avium complex pulmonary disease (MAC-PD) has been increasing. Diagnosis requires identification of pathogens on multiple occasions in addition to characteristic observation of lesions on imaging examinations, identification of pathogens on bronchoscopic examination, or other pathological evidence. As a result, the diagnosis is non-definitive in many patients who produce no sputum and do not wish to undergo bronchoscopic examination. Glycopeptidolipid (GPL)-core antibody to MAC is an easy serological test. Therefore, GPL-core antibody may be useful for diagnosing MAC-PD.Aims: This study aimed to estimate the usefulness of GPL-core antibody for diagnosing MAC-PD by investigating patients who were positive for GPL-core antibody.Method: A total of 66 patients who were positive for GPL-core antibody were retrospectively investigated, and their characteristics were evaluated. The cut-off value for a positive finding was 0.7 U/mL.Results: The median GPL-core antibody titer was 2.75 U/mL. Overall, 27 patients with MAC-PD met the ATS guidelines, and 11 were positive once on sputum culture. The mean antibody titer was 5.65 U/mL with identification of pathogens and 3.61 U/ml without (p=0.089). On chest computed tomography (CCT), 48 patients showed micronodular shadows and divergent shadows, and 48 showed bronchodilation. The mean antibody titer was higher in patients with than without these shadows on CCT (p=0.0014, p<0.0001).Conclusion: GPL-core antibody titer was higher in patients with MAC-PD when shadows were seen on CCT. Therefore, GPL-core antibody is useful for diagnosing MAC-PD.