RT Journal Article
SR Electronic
T1 Late-breaking abstract: New algorithm of lung cancer diagnosis by analysis of exhaled breath with electronic nose and multifactorial logistic regression method
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 3288
VO 44
IS Suppl 58
A1 Maris Bukovskis
A1 Normunds Jurka
A1 Gunta Strazda
A1 Ainis Pirtnieks
A1 Uldis Kopeika
A1 Madara Tirzite
A1 Immanuels Taivans
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/3288.abstract
AB BackgroundExhaled breath of lung cancer patients contains unique pattern of volatile organic compounds (VOCs) which can be distinguished by analysis with electronic nose.ObjectiveThe aim of our study was to develop optimal diagnostic algorithm by multifactorial logistic regression (MLRA) analysis and test its diagnostic potential in patients with lung cancer.MethodsExhaled breath of lung cancer patients (cancer group) and mixed group of patients (COPD, asthma, pneumonia) and healthy volunteers (no cancer group) was examined. Exhaled air was collected using standardized method and sampled by electronic nose (Cyranose 320). Optimal detector parameter combination and mathematical model for discrimination of lung cancer was computed by MLRA backward step-wise method in smokers, ex-smokers and nonsmokers. Sensitivity, specificity, positive (PPV) and negative predictive value (NPV) of the algorithms in the training sample of each group was calculated.ResultsTotal 474 patients, out of them 282 lung cancer patients and 192 patients with different lung diseases and healthy volunteers were recruited in the study. 129 were nonsmokers, 135 ex-smokers and 210 smokers.View this table:Accuracy of diagnostic algorithms for smokers, ex-smokers and nonsmokersConclusionsFinding of optimal detector parameter combination and splitting of patients in smokers, ex-smokers and nonsmokers gives very high lung cancer prediction accuracy.AcknowledgementsStudy was sponsored by ERAF activity 2.1.1.1.0 Project Nb. 2010/0303/2DP/2.1.1.1.0/10/APIA/VIAA/043/