RT Journal Article
SR Electronic
T1 Increased systemic inflammation in cystic fibrosis (CF) is associated with deterioration in lung clearance index (LCI)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1206
VO 44
IS Suppl 58
A1 Joseph Stuart Elborn
A1 Katherine O'Neill
A1 Elinor Johnston
A1 Judy M. Bradley
A1 Stephen Rowan
A1 Alastair Reid
A1 Michael M. Tunney
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P1206.abstract
AB LCI is a robust measure of ventilation distribution in CF. There are no data demonstrating a relationship between LCI and biomarkers of systemic inflammation during clinical stability.Objective: To investigate the relationship between C-reactive protein, (CRP), White Cell Count (WCC) and LCI in CF. Methods: Stable CF patients from Northern Ireland CF centres, aged ≥ 6 years were recruited. LCI was derived from multiple breath washout. Blood CRP and WCC were measured by turbidimetric immunoassay. Spearman correlation coefficient was used. Results: n=83 (table 1).View this table:Table 1: CF patient characteristicsCRP (figure 1) and WCC (figure 2) had a significant correlation with LCI. Similarly, there was a significant correlation between CRP (r=-0.37; p=0.0006),WCC (r=-0.47; p<0.0001) and FEV1% pred.Conclusion: Increased systemic inflammation in CF is associated with deterioration in LCI.Funder: US-Ireland Project Partnership Grant.