PT  - JOURNAL ARTICLE
AU  - Joseph Stuart Elborn
AU  - Katherine O'Neill
AU  - Elinor Johnston
AU  - Judy M. Bradley
AU  - Stephen Rowan
AU  - Alastair Reid
AU  - Michael M. Tunney
TI  - Increased systemic inflammation in cystic fibrosis (CF) is associated with deterioration in lung clearance index (LCI)
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P1206
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P1206.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P1206.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - LCI is a robust measure of ventilation distribution in CF. There are no data demonstrating a relationship between LCI and biomarkers of systemic inflammation during clinical stability.Objective: To investigate the relationship between C-reactive protein, (CRP), White Cell Count (WCC) and LCI in CF. Methods: Stable CF patients from Northern Ireland CF centres, aged ≥ 6 years were recruited. LCI was derived from multiple breath washout. Blood CRP and WCC were measured by turbidimetric immunoassay. Spearman correlation coefficient was used. Results: n=83 (table 1).View this table:Table 1: CF patient characteristicsCRP (figure 1) and WCC (figure 2) had a significant correlation with LCI. Similarly, there was a significant correlation between CRP (r=-0.37; p=0.0006),WCC (r=-0.47; p<0.0001) and FEV1% pred.Conclusion: Increased systemic inflammation in CF is associated with deterioration in LCI.Funder: US-Ireland Project Partnership Grant.