RT Journal Article
SR Electronic
T1 Late-breaking abstract: HRCT comparisons of tobacco smoking (TS-COPD) and biomass smoke induced COPD (BS-COPD) phenotypes from an Indian rural setting
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P638
VO 44
IS Suppl 58
A1 Komalkirti Apte
A1 Bill Brashier
A1 Jyoti Londhe
A1 Sapna Madas
A1 Sundeep Salvi
A1 Arjun Nair
A1 SM Mun
A1 Peter Barnes
A1 David Hansell
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P638.abstract
AB Although biomass smoke associated COPD (BS- COPD) is highly prevalent in India and other developing countries, there is paucity of knowledge whether this COPD is morphologically similar or different from tobacco-smoke associated COPD (TS-COPD). Aim: To compare lung-HRCT patterns of BS-COPD with that of TS-COPD and healthy subjects. Method: Inspiratory and expiratory axial HRCT images were obtained from 42 BS-COPD, 38 TS-COPD, 20 healthy biomass exposed ( BS-Healthy) and 14 Healthy-smokers (TS-Healthy) subjects from a rural setting in India. Lung abnormalities were evaluated at the parenchymal and airway levels using visual semi-quantitative scoring of HRCT morphology by two independent experienced radiologist. The parenchymal patterns were scored at a lobar level to the nearest 5%, and the airways abnormalities were graded on a four point scale. Results: Compared to TS-COPD, subjects with BS-COPD had significantly lower mean sum emphysema scores (265.±343 vs 40±70, p&lt;0.001), and significantly higher mean "low attenuation area" (LAA) scores (479±233 vs 279±238, p=0.004). "Bronchial wall thickening scores " and "tree in bud scores" were similar in TS-COPD and BS-COPD (p&gt;0.05). The Mean sum emphysema scores and LAA scores amongst TS-Healthy and BS-healthy were significantly lower than TS-COPD and BS-COPD ( both p&lt;0.05), with no significant differences between the healthy groups(p&lt;0.05) Conclusion: Indian subjects with BS-COPD had lower emphysema but higher air-trapping compared to TS-COPD, suggesting primarily a small airway pathology.