TY - JOUR T1 - Parents having worked as cleaners and offspring's atopic eczema JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - 407 AU - Randi J. Bertelsen AU - Hilde Kristin Vindenes AU - Trude Duelien Skorge AU - Tor Aasen AU - Bryndís Benediktsdóttir AU - Shyamali Dharmage AU - Bertil Forsberg AU - Thorarinn Gislason AU - Mathias Holm AU - Christer Janson AU - Rain Jogi AU - Dan Norbäck AU - Lars Modig AU - Ernst Omenaas AU - Francisco Gomez Real AU - Vivi Schlünssen AU - Torben Sigsgaard AU - Kjell Toren AU - Gunilla Wieslander AU - Ane Johannessen AU - Øistein Svanes AU - Cecilie Svanes Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/407.abstract N2 - Background: Parents' exposure to cleaning chemicals may impact children's health, either through a direct effect on the child from exposure to cleaning agents or through immunologically transferred effects between generations. We aimed to assess whether ever having worked as a cleaner is a risk factor for eczema in the offspring.Method: Occupational history as a cleaner and atopic eczema in the child (from parental questionnaires) was retrieved from the Respiratory Health in Northern Europe (RHINE III) study in 2012. We used a random-effects regression model to estimate the odds of atopic eczema if the parents had ever worked as a cleaner. The model included 9,445 35-67 year olds and their 21,810 offspring (0-51 years old). Analyses were adjusted for parental history of asthma, dampness/mold at home, parental educational level, parental smoking, parents' gender, age of children and parents (at data collection), study center, and family clustering.Results: The odds for offspring's eczema (16%) was increased if either the mother or father had ever worked as a cleaner (16%), OR = 1.24 (95% CI: 1.09, 1.42). The odds for offspring's eczema was OR=1.20 (95% CI: 1.04, 1.49) if it was the mother who had worked as a cleaner (22%) and OR=1.46 (95% CI: 1.10, 1.94) if it was the father who had worked as a cleaner (9%).Conclusion: Children of parents who reported to ever having worked as cleaners had more often atopic eczema than children of parents who had never worked as cleaners. Although we cannot exclude the possibility of unmeasured confounding, a potential trans-generational association between parental exposure to cleaning agents and eczema in the offspring should be further examined. ER -