TY - JOUR T1 - Short term effects of tobacco smoking on exhaled breath temperature JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - 1399 AU - Tanya Kralimarkova AU - Diana Hristova AU - Ryan Kadavil AU - Jasmine John AU - Jacquilin Sabu AU - Vasil Dimitrov AU - Todor Popov Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/1399.abstract N2 - Background:Exhaled breath temperature (EBT) has been demonstrated to be an integral indicator of both inflammation and remodeling in the airways. We have shown that EBT in smokers drops over time proportionally to the cumulative load of tobacco smoking (in pack years). However, more insight is needed for mechanisms of action of daily smoking on the airways wall. The aim of this study was to explore the short term influence of smoking on EBT.Methods: We compared baseline EBT measured in the morning in 41 smokers without overt signs of COPD, mean age 35±20 (standard deviation, SD) years, 16 males, and in 38 non-smokers (37±14 years, 13 males. We also measured EBT in the smokers before and 15 minutes after smoking the first cigarette for the day. In a separate experiment we compared EBT at 8 a.m. and 1 p.m. in 63 subjects: 25 smokers, 40±16 years, 11 males, and 38 non-smokers , 40±16 years, 13 males. The devices we used were hand-held breath thermometers (X-Halo, Delmedica Investments LTD Singapore).Results: Baseline morning EBT was higher in smokers than in non-smokers: 34,38 (mean) ±0.08 (s.e.m.) °C vs. 33,94±0.16°C, P = 0.015. After the first cigarette for the day, EBT of smokers increased from 34.38±0.08°C to 34,57±0.08°C, P = 0.004. While EBT in non-smokers decreased in the course of the day, EBT of smokers increased: between groups difference was 0.42±0.07°C, P=0.02. No gender differences were outlined.Conclusions: Smokers without overt COPD have higher baseline EBT than age matched non-smokers; smoking their first cigarette for the day increases EBT. In addition, smoking is associated with a different circadian pattern of EBT during the day. Smoking sustains airway inflammation on a daily basis. ER -