PT  - JOURNAL ARTICLE
AU  - Inga Heinzelmann
AU  - Rainer Gloeckl
AU  - Michael Dreher
AU  - Emelie Ekkernkamp
AU  - Claudia Schmoor
AU  - Ursula Schoenheit-Kenn
AU  - Sandra Winterkamp
AU  - Klaus Kenn
TI  - Feasibility and effects of non-invasive ventilation during pulmonary rehabilitation in patients with hypercapnic interstitial lung disease
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P627
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P627.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P627.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - BackgroundAim of this study was to investigate the feasibility and the effects of non-invasive ventilation (NIV) during pulmonary rehabilitation (PR) in hypercapnic patients with interstitial lung disease (ILD).MethodsIn this retrospective analysis hypercapnic (NIV initiated) and normocapnic ILD-patients admitted to a specialized PR were analyzed. Standardized PR was performed in all ILD-patients. Pulmonary function tests, blood-gas analysis, 6-min walk distance (6MWD) and a health-related quality of life (HRQL) (SF-36) were assessed on admission and discharge.ResultsData of 29 ILD-patients with NIV (PR for 25±19 days) were compared with those of 319 normocapnic ILD-patients (PR for 25±13 days). In contrast to the normocapnic group, NIV patients were initially more impaired regarding PaO2, PaCO2, vital capacity (all p<0.0001), total lung capacity (p=0.012) and O2 demand (p=0.041). PR was associated with an improvement in 6MWD of 64 meters (95% CI [45 - 84], p<0.0001) in NIV patients, and of 43 meters (95% CI [37 - 49], p<0.0001) in the non NIV-patients (difference 21 meters, 95% CI [0.5, 41.8], p=0.045). In NIV-patients pCO2 levels dropped slightly from 50.6±9.0 to 49.0±6.4 mmHg during PR. PR with NIV improved mental health summary score (SF-36) (9.3, 95% CI [4.8 - 13.9], p<0.0001) but not physical summary score (0.7, 95% CI [-2.1 - 3.4], p=0.63). There was no difference between the two groups with regard to changes in HRQL. No adverse events were registered in patients with NIV during PR.ConclusionsNIV during PR in ILD-patients seems to be feasible and safe. It may improve exercise capacity and HRQL even in patients with hypercapnic ILD.