PT - JOURNAL ARTICLE AU - Samira Aouadi AU - Asma Sebai AU - Houda Gharsalli AU - Houda Snene AU - Najla Ghrairi AU - Sonia Maalej AU - Leila El Gharbi TI - Interstitial lung disease in the connective tisssue disease DP - 2014 Sep 01 TA - European Respiratory Journal PG - P715 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P715.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P715.full SO - Eur Respir J2014 Sep 01; 44 AB - Introduction: Interstitial lung disease (ILD) is one of the most serious pulmonary complications associated with connective tissue diseases (CTD), resulting in significant morbidity and mortality. Usually, ILD occur in patients with diagnosed CTD. However, ILD can be the revealing manifestation of the disease.Objective: To describe clinical, radiological and laboratory finding in ILD associated with CTD.Methods: A retrospective study including all patients hospitalized between 2008 and 2013 for ILD associated with CTD was conducted in respiratory department D of A. Mami hospital.Results: twenty-five patients were includes (23 women, 2 men). Mean age was 55 years (29-78 years). CTD was previously diagnosed in 10 patients with a mean duration of 8 years. In 15 cases, the ILD was the revealing manifestation of the disease. Clinical extra pulmonary manifestations of CTD were found in 15 patients. The main CTD were Rheumatoid arthritis (n=10), poly-/dermatomyositis (n=6), Sjögren's syndrome (n=4), systemic lupus erythematosus (n=3) and systemic sclerosis (n=2). Non-specific interstitial pneumonia was the most commonly observed pattern (n=13). The other patterns were usual interstitial pneumonia (n=9), organizing pneumonia (n=3). Serum antibodies were helpful in diagnosis of CTD in 23 cases. ILD was responsible for chronic respiratory failure in 4 cases and death in 2 cases.Conclusion: The possibility of CTD should be considered in patients with ILD. Careful examination and serum antibodies are very important for an early diagnosis of this association.