PT - JOURNAL ARTICLE AU - Can Sevinc AU - Kemal Can Tertemiz AU - Aylin Ozgen Alpaydin AU - Hulya Ellidokuz AU - Cagdas Acara AU - Arif Hikmet Cimrin TI - Correlation between red cell distribution width and disease severity and mortality in COPD patients DP - 2014 Sep 01 TA - European Respiratory Journal PG - P520 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P520.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P520.full SO - Eur Respir J2014 Sep 01; 44 AB - AIM: Erythrocyte morphology changes not only by primary hematological malignancies but also by systemic inflammation, ineffective eritropoesis, and nutritional deficiencies. This influence can be evaluated by “red blood cell (RBC) distribution width (RDW)”. We aimed to investigate the relationship of RDW with disease stage, BODE index and survival in COPD patients.METHOD: Medical records of 385 COPD patients who were being followed–up from 2005 were studied retrospectively. Demographic features and BODE indices of patients that were classified according to GOLD 2009 were recorded. Survival analysis of all patients by 2014 was performed. Measured RDW values were evaluated.RESULTS: Mean age of the patients was 65.6±9.6. COPD stage of the patients were stage 1; 16%, stage 2; 52%, stage 3; 26%, stage 4; 56%. Median of BODE index was (0-3). As the BODE index increased RDW also increased (r=0.383 p=0.000). RDW was found significantly different between stages, the highest RDW was in the very severe stage (p=0.000). When the patients were grouped according to the laboratory upper limit of RDW, survival rate was 31% in the RDW>14.3 group and %75 in the RDW<14.3 group.CONCLUSION: Erythrocyte morphology deteriorates as the severity of the diseases progresses. Therefore, RDW; a simple and noninvasive test might be used as preliminary biomarker in the evaluation of diseases severity. At the same time, the close correlation between survival and RDW can be meaningful for the prognosis prediction.