TY - JOUR T1 - Bronchial thermoplasty in patients with poorly controlled asthma: Three cases JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P3731 AU - Turhan Ece AU - Zuleyha Bingol AU - Zeynep Yegin Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P3731.abstract N2 - Introduction: Bronchial thermoplasty (BT) is a new technique for uncontrolled asthma. It delivers thermal energy to the large airways and decrease the amount of smooth muscle. BT has been shown to reduce asthma exacerbations, and improve asthma control and quality of life.Metods: Stable adult asthmatics requiring optimal inhaler treatment (beclomethasone ≥200μg, salmeterol ≥100μg), post-bronchodilator FEV1 50-80% predicted; and, non- smoker for 1yr or former smoker <10pack-year were included. Three seance BT were done.Case I: A 45year-old male with uncontrolled asthma for 20 years, underwent BT. He had been receiving optimal medical therapy with p.o prednisolone 8mg/daily. Symptoms did not persist after BT. FEV1 prior to BT was 65% (1830ml), ACQ: 4, ACT:11. During 12 week follow-up, FEV1: 44% (1480ml), ACQ:1 and ACT:23.Case II: A 45year-old female with uncontrolled asthma for 14 years underwent BT. She were receiving optimal medical therapy with p.o prednisolone 16mg/daily and omalizumab. FEV1 prior to BT was 82% (3610ml), ACQ: 5,5, ACT: 5. During 12 weeks follow-up, FEV1 was 89% (3940ml), ACQ: 0,2 and ACT: 25.Case III: A 40-year-old male with uncontrolled asthma for 20 years, underwent BT. He had been receiving optimal medical therapy with p.o prednisolone 16mg/daily. Heamoptysis (10cc) occured a week after third seance. Symptoms improved after BT. FEV1 prior to BT was 66 % (2370ml), ACQ:2.7, ACT:5. During 12 week follow-up, FEV1:65% (2340ml), ACQ:0.8 and ACT:25.Conclusion: Response to BT varies from one patient to another. Further studies with different asthma phenotypes are required to define the better responders from BT. ER -