@article {ParpievaP2587, author = {Nargiza Parpieva and Vera Beloserkoves and Khasan Safaev and Aziz Shakirov}, title = {Mutations in the genes of drug-resistant mycobacterium tuberculosis in Uzbekistan}, volume = {44}, number = {Suppl 58}, elocation-id = {P2587}, year = {2014}, publisher = {European Respiratory Society}, abstract = {Aim of research to study the prevalence of drug resistance in Mycobacterium tuberculosis circulating in various regions of Uzbekistan.Materials and methods: In 2013 were tested 1438 patterns for drug susceptibility. The sensitivity of the MBT to anti TB drugs was determined using a diagnostic kit GenoType{\textregistered} MTBDRplus.Results and discussion: Among the examined patient 793 (55\%) were men, women were 645 (45\%). By the instrumentality of a diagnostic kit GenoType{\textregistered} MTBDRplus in 40.4\% (580) of patients identified sensitive strains of MBT to isoniazid (INH) and rifampicin (RIF). Mutations in the rpoB, katG, inhA genes were found in 59.6\% (858) of patients. Mono-resistance to INH was detected at 13\% (188) cases. Mono-resistance to RIF was founded at 2.6\% (37) patients. In 44\% (633) cases identified multi drug resistance (MDR) strains of the MBT, at the same time resistant to RIF and INH.Regional distribution of drug resistance strains:1.Mono resistance to INH: Tashkent region 30.3\% (57 out of 188),Tashkent city 17.5\%, Samarqand region 9.5\%2.Mono resistance to RIF: Fergana region 24.4\% (9 out of37), Tashkent region 16.2\%, Namangan region 13.5\%3.MDR strains: Fergana region 20.9\% (132 out of 633), Tashkent region 18.3\%, Andijan region 17\%, Tashkent city 19.3\%Conclusion: Thus, in the structure of drug resistance strains dominated MDR strains (44\%). The largest number of cases with mono-resistance to RIF occurred in the Fergana region (24.4\%) and mono-resistance to INH in the Tashkent region (30.3\%). MDR strains of MBT were more common at Fergana (20.9\%) and Andijan (17\%) regions. Further inquiry of the problem continues.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/P2587}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }