RT Journal Article
SR Electronic
T1 Gender differences in comorbidity burden in recently diagnosed obstructive sleep apnea patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2199
VO 44
IS Suppl 58
A1 Maria Xanthoudaki
A1 Evangelia Nena
A1 Maria Antoniadou
A1 Panagiotis Boglou
A1 Stylianos Steiropoulos
A1 Paschalis Ntolios
A1 Maria Manidou
A1 Kostas Archontogeorgis
A1 Georgios Kolios
A1 Demosthenes Bouros
A1 Paschalis Steiropoulos
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2199.abstract
AB Background: Obstructive Sleep Apnea (OSA) is associated with several comorbidities. Aim of the study was to examine gender differences in comorbidities in a large line of OSA patients.Methods: The characteristics of 689 consecutive individuals (511 males and 178 females) evaluated with polysomnography, due to suspected OSA, were analyzed. Patients were divided according to OSA severity into 3 groups and comparisons were made between male and female patients.Results: Mild OSA was diagnosed in 142, moderate in 105 and severe OSA in 303 patients. In 139 individuals, AHI was <5/h (these served as controls). Mean number of comorbidities increased with OSA severity (1.5±1.3 in mild, 1.7±1.4 in moderate, and 1.8±1.6 in severe OSA; p=0.048).Among OSA patients, females were older (56.2±10.9 vs. 52.8±13.3 years, p=0.001) with higher BMI (36±8.7 vs. 32.9±5.9 Kg/m2, p<0.001). A significantly higher total number of comorbidities (2.3±1.6 vs. 1.6±1.4; p<0.001) in women vs. men was observed. This difference was not observed in controls. Smoking prevalence (current or ex-smokers) was significantly higher in men (75% vs. 46.2%, chi-squared 35.107, p<0.001).Females with OSA had a higher prevalence of hypothyroidism (21.4% vs. 2.9%, chi-squared 48.145, p<0.001), depression (13.7% vs. 1.9%, chi-squared 29.239, p<0.001), arterial hypertension (58.1% vs. 45.7%, chi-squared 5.677, p=0.021) and heart failure (6% vs. 1.7%, chi-squared 6.490, p=0.019) in comparison with males.Conclusion: Women recently diagnosed with OSA, are older and more obese, with higher burden of comorbidities than men. Hypothyroidism, depression, arterial hypertension and heart failure are more prevalent in women with OSA than men.