PT  - JOURNAL ARTICLE
AU  - Nebal Abu Hussein
AU  - Evelyne Sonderer
AU  - Pierre-Olivier Bridevaux
AU  - Prashant Chhajed
AU  - Jean-William Fitting
AU  - Thomas Geiser
AU  - Ladina Joos Zellweger
AU  - Malcolm Kohler
AU  - Sabrina Maier
AU  - David Miedinger
AU  - Salome Schafroth Tötök
AU  - Robert Thurnheer
AU  - Michael Tamm
AU  - Jörg Daniel Leuppi
TI  - Disease progression and changes in risk groups' classification over a period of one year in the GPs based Swiss chronic obstructive pulmonary disease (COPD) cohort
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P798
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P798.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P798.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Background: COPD is known to be a progressive disease. Our objective was to analyze the progression of the disease over a time of twelve months in a general practitioners' (GPs) based Swiss COPD cohort.Methods: COPD patients were screened and enrolled into our cohort. Demographic data was collected; medical treatment, spirometric parameters and exacerbation history were recorded every six months. Classifying COPD patients into risk groups were determined using mMRC and COPD Assessment Test (CAT).Results: 130 COPD patients (61% male, 38% current smoker) were analyzed at baseline and after 12 months. At baseline, 50% of the patients were in risk group A, 3% in group B, 30% in C and 17% in risk group D using mMRC and 19% in group A, 34% B, 11% C and 36% D using CAT. After twelve months, 45% of the patients were in group A, 6% in B, 32% in C and 17% in risk group D using mMRC and 18% A, 32% B, 13% C and 37% D using CAT. There was a decrease of lung function (FEV1%) of 2% in all patients (p-value 0.03). FEV1, pulmonary rehabilitation and CAT were good baseline predictors for changes in disease progression.Conclusion: Classifying COPD patients into risk groups A-D using CAT or mMRC might provide different results. Lung function and symptom changes could not be detected in a short time span of one year, the results showed neither significant improvement nor impairment related to mMRC or CAT score.