%0 Journal Article %A Bertram Jobst %A Jürgen Biederer %A Iven Fellhauer %A Julia Schliebus %A Annette Opgenorth %A Claus-Peter Heussel %A Hans-Ulrich Kauczor %T Establishment of the image bank within the German COPD cohort COSYCONET %D 2014 %J European Respiratory Journal %P P640 %V 44 %N Suppl 58 %X Introduction: Imaging data play an increasing role in phenotyping and phenotype-genotype correlations of COPD with regard to an airway- or emphysema-type and additional subphenotypes. Within the COSYCONET cohort an image bank has been installed collecting all available chest CTs from the participants regardless of time of acquisition.Methods: After pseudonymisation CT data underwent qualitative analysis: lobar-based assessment of presence or absence of abnormalities related to large or small airways and estimation of extent of emphysema. Quantitatively, emphysema was assessed by mean lung density, low attenuation area percent and 15 percentile; airways were assessed with regard to wall thickness and wall area percent.Results: 412 CT data sets from 24 centers were collected until 12/2013. 86 % of the scans were less than 4 years old. The clinical indication was emphysema/COPD in 67 % of patients, nodule or lung cancer in 15 % and only 8 % for infiltrates. 40 % of scans were contrast-enhanced, which carries inherent difficulties for the quantitative analysis of emphysema. 55 % of the scans had a slice thickness of 3 mm or less, which is deemed adequate. Airway type is more frequent in lower GOLD stages, whereas emphysema extent gradually increases with GOLD stage.Conclusions: The retrospective collection of CTs reflects the clinical reality in imaging COPD. It represents an important repository for phenotyping. Due to the shortcomings, a prospective study comparing MRI and CT for phenotyping COPD was initiated in a subcohort of COSYCONET in December 2013.Supported by Competence Network Asthma/COPD, funded by FM of Education and Research, FKZ 01GI0884. %U