RT Journal Article
SR Electronic
T1 Late-breaking abstract: Efficacy of inhaled N-acetylcystein in patients with interstitial pneumonia
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4500
VO 44
IS Suppl 58
A1 Ryo Okuda
A1 Tomohiro Ohba
A1 Tomotaka Nishizawa
A1 Rie Kawabe
A1 Koujiro Honda
A1 Masako Amano
A1 Hidekazu Matsushima
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P4500.abstract
AB Background: An oxidant-antioxidant imbalance may be associated with the disease process in Idiopathic pulmonary fibrosis (IPF). N-acetylcystein might contribute to a reversal of the oxidant-antioxidant imbalance. The inhalation of N-acetylcystein might be the best way of reaching N-acetylcystein to respiratory epithelial lining fluid. Furthermore, the efficacy of inhaled N-acetylcystein in patients with secondary interstitial pneumonia remains unclear.Aim: To assesse the clinical efficacy of inhaled N-acetylcystein therapy in patients with interstitial pneumonia.Methods: The study design was a prospective, single-arm study of the clinical effects of inhaled N-acetylcystein in patients with interstitial pneumonia who visited one institute in Saitama, Japan, between January 1 and December 31, 2013.Results: A total of 40 patients were included. The patients with interstitial pneumonia were diagnosed as follows: IPF, 29 cases; idiopathic nonspecific interstitial pneumonia, 5 cases; connective tissue disease, 5 cases; and chronic hypersensitive pneumonitis, 1 case. The mean change in FVC during the 6 months after N-acetylcystein therapy was -10 mL. The effect of N-acetylcystein was only examined in patients (n = 28) who had conducted a respiratory function test at 6 months before the initiation of therapy. The mean change in FVC during 6 months prior to the N-acetylcystein therapy was -127 mL, while the mean change in FVC during 6 months after the initiation of therapy was -19 mL. The absolute serum level of KL-6 decreased significantly from 1372 U/mL to 1065 U/mL after the therapy. Conclusions: These results showed that inhaled N-acetylcystein had a beneficial effect in patients with interstitial pneumonia.