PT  - JOURNAL ARTICLE
AU  - Faycal Bali
TI  - The allergy to insulin about a case treated by montelukast
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P4025
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P4025.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P4025.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - The insulin allergy is IgE and is manifested by cutaneous form of local reactions erythema and swelling at the injection or generalized urticarial site. Flare reactions appear in the ancient sites of insulin injection. There may be itching to planto palmar and hot generalized heat.More serious accidents with angioedema anaphylaxis and with hypotension dyspnea resulting death are not uncommon.An 18 Years diabetes patient insulin-dependent since 6 Years. He has been for one year repeated episodes of edema with Quick asphyxia and hypotension. Occurred to after the injection of insulin became pruriginous. Spaced and serious crisis from a few weeks to a few months with complete remission between attacks. Some episodes of isolated predominantly damage to nival old insulin injections site urticaria. Persistence of these episodes despite several changes of insulin mark.The diagnosis was confirmed by specific IgE which strongly positive human insulin. The role of additives (Zinc, Latex, and Protamine) is excluded. The intradermal different type of insulins was all positive. We put our patient on 10mg of Montelukast and we observed a complete regression of symptoms checked after falling 26 months.The insulin allergy is a serious disease and reported therapeutic strategy was disappointing and complicated. This was a change in insulin, desensitization, desensitization and corticosteroid; desensitization and anti- IGE; see pancreas transplant.Our report describes the first successful therapy in a diabetic patient with a severe allergy to insulin, which Montelukast has been applied to long term.