PT  - JOURNAL ARTICLE
AU  - Héctor Eduardo Riera Ave
AU  - Carles Bravo
AU  - Berta Sáez
AU  - Teresa Tórtola
AU  - Fernando Ruiz
AU  - Cristina Berastegui
AU  - Manuel Lopez Meseguer
AU  - Victor Monforte
AU  - Antonio Román
TI  - Non-tuberculous mycobacterium infection in lung transplant recipients
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P3313
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P3313.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P3313.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - BACKGROUND: Non-tuberculous mycobacterial (NTM) infections are relatively frequent in lung transplant (LT) recipients and they might be associated with increased morbi-mortality.METHODS: We did a retrospective and observational review of LT recipients from whom NTM were isolated between 2002 and 2013 (n=539) that had at least one NTM positive culture, to study the incidence, clinical manifestations, treatment and outcomeRESULTS: 25 patients had NTM positive cultures. 72% were men, the mean age was 46.75 years (r 7-63). 72% were bilateral LT recipientsMost frequent culture sources were tracheal aspirate, sputum, bronchoalveolar lavage. 44% had positive perioperative cultures (2 of the donor and 9 of the recipient), 56% were diagnosed during follow up, with a mean of 283.92 days post LT (r 20-1291). 3 patients had NTM infection prior to the LT.56% patients developed NTM disease and were treated. Most frequent symptoms were cough, bronchorrea and dyspnea. 6 patients developed NTM extrapulmonary disease. Most frequent radiologic findings were pulmonary nodules, consolidations, and ground glass opacities.The most frequent NTM were M. abscessus 24%, M. gordonae 20%, M. fortuitum 12%, M. immunogenum 12%. 1 presented concomitant M. avium and M. tuberculosis infection. 28% patients that had NTM infection died, mean of 670,14 days post LT (r 55-2173), 1 of them by disseminated M. abscessus diseaseCONCLUSIONS: Incidence of NTM infection among LT recipients in our center between 2002-2013 is 4,63% (disease 2,59% , colonization 2,04%)The most frequent NTM were M. abscessus, M. gordonae, M. fortuitum.NTM infection prior to the LT increases the risk of NTM infection post LT1 of the deaths was linked directly to NTM.