@article {YazakiP3595, author = {Kenji Yazaki and Naoko Kamada and Kenichi Asakura and Rei Oba and Etsuko Sato and Mitsuko Sato and Tazuko Sato and Kenji Kikuchi}, title = {Characteristics of pulmonary function of COPD with and without arterial pulmonary hypertension}, volume = {44}, number = {Suppl 58}, elocation-id = {P3595}, year = {2014}, publisher = {European Respiratory Society}, abstract = {Patients with low levels of diffusing capacity of the lung for carbon monoxide (Dlco) do not always have pulmonary arterial hypertension (PAH) as part of chronic obstructive pulmonary disease (COPD).The aim of this study is to investigate the characteristics of pulmonary function of COPD with and without PAH and compare ratios of vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), or inspiratory capacity (IC) to Dlco versus alveolar volume (Dlco/VA)All subjects who needed oxygen therapy and also underwent lung function testing and Doppler echocardiography were reviewed, retrospectively, from September 1, 2011, to January 31, 2014. Fifteen subjects, all ex-smokers, were included(80.6{\textpm}6.6 age, FEV1 \% 41.16{\textpm}13.15\%, FEV1 \%predicted 49.14{\textpm}19.61\%, Dlco 5.00{\textpm}2.83ml/min/mmHg). PAH was defined as the estimated systolic pulmonary arterial pressure (sPAP)>=40mmHg at rest and a diagnosis of PAH by cardiologists. There was no heart failure among any of the subjects with PAH.Six subjects had PAH. In the non-PAH group, Dlco was 4.94{\textpm}1.40 ml/min/mmHg, and Dlco/VAwas 1.12{\textpm}0.41 ml/min/mmHg/L. In the PAH group, Dlco was 5.08{\textpm}4.38 ml/min/mmHg, and Dlco/VA was 0.95{\textpm}0.59 ml/min/mmHg/L. There were no significant differences between non-PAH and PAH. In the ratio of average PAH to non-PAH, VC/Dlco/VAwas 1.91, FVC/Dlco/VA was 1.87, FEV1/Dlco/VA was 2.01, and IC/Dlco/VA was 2.13. All subjects in the PAH group were significantly correlated with sPAP(r=0.771, 0.771, 0.942, and 0.829, respectively, p\<0.05).This report suggests that VC/Dlco/VA, FVC/Dlco/VA, FEV1/Dlco/VA, and IC/Dlco/VA might be useful to assist in diagnosing PAH in COPD.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/P3595}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }