TY - JOUR T1 - Clinical characteristics of chronic pulmonary aspergillosis and colonization; retrospective analysis of patients with isolation of asperguillus species from respiratory samples JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2467 AU - Sayaka Ohara AU - Yoko Tazawa AU - Hajime Horiuchi AU - Kazuhiro Usui Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2467.abstract N2 - Background and Aim of Study: With the advancement of anti-fungal drugs, it becomes more important to diagnose Chronic Pulmonary Aspergillosis (CPA). The aim of this study is to clarify the clinical characteristics of CPA.Methods: We retrospectively extracted 110 patients with isolation of Aspergillus species from respiratory samples (sputum or broncho lavage fluid) between 01/2001 and 12/2011. We divided patients into three groups; CPA, ABPA, and colonization and compared the clinical characteristics of the patients with CPA to those with colonization.Results: Median age of patients was 71 years-old (range 31-92). There were 46 women (42%). The most frequent Aspergillus species isolated was Aspergillus fumigatus (N=58), followed by Aspergillus niger (35), Aspergillus flavus (10), Aspergillus terreus (3), Aspergillus nidulans (1), and Aspergillus spp (13).Thirty (27.4%) were diagnosed with CPA, whereas 75 (68.2%) with colonization and 5 (4.5%) with ABPA. Compared with colonization, CPA included more men (CPA vs colonization; 49.3% vs 13.3%), with low BMI (18.45kg/m2 vs 21.09kg/m2). CPA patients had a significantly higher prevalence of sequalae of pulmonary tuberculosis (40% vs 8%) and a history of thoracic surgery (43% vs 13%) than colonization. Bronchial asthma is less frequent in CPA group than colonization (0% vs 20%). Positivity of Aspergillus antigen is higher in CPA group than colonization group (64% vs 14%). CPA patients have significantly shorter survival than colonization (median survival time:1126 days vs not reached ).Conclusion: CPA shows distinct clinical characteristics from colonization. ER -