RT Journal Article SR Electronic T1 Aerobic training inhibits bleomycin-induced pulmonary fibrosis in BALB/c mice JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P871 VO 44 IS Suppl 58 A1 Ana Roberta Almeida-Oliveira A1 Paulo Rogério Pereira A1 Flavia Regina Greiffo A1 Nicole Cristina Rigonato-Oliveira A1 Adilson Andrade-Sousa A1 Jefferson Comin A1 Manoel Oliveira-Junior A1 Ricardo Wesley Custodio A1 Regiane Albertini A1 Ana Paula Ligeiro Oliveira A1 Oliver Eickelberg A1 Rodolfo de Paula Vieira YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/P871.abstract AB Idiopatic pulmonary fibrosis (IPF) is a devastating disease with poor prognostic and no effective treatment is available. Although there are a considerable number of studies showing that pulmonary rehabilitation programs for IPF patients results in improved quality of life and disease management, the possible mechanisms involved in this beneficial effects remains to be elucidated. Therefore, the present study investigated the effects of low intensity treadmill aerobic training in an experimental model of pulmonary fibrosis induced by bleomycin in BALB/c mice. The results show that aerobic exercise reduced the number of total cells and neutrophils in bronchoalveolar lavage (p<0.001), reduced the amount of collagen fibers deposition in airways wall (p<0.01), as well as reduced the levels of IL-1beta, IL-6, KC and TNF-alpha in bronchoalveolar lavage fluid, while increased the levels of anti-inflammatory cytokine IL-10 (p<0.01). We conclude that aerobic training inhibits the fibrotic and inflammatory response in a model of pulmonary fibrosis induced by bleomycin...