RT Journal Article
SR Electronic
T1 Fever, hospitalization and healthcare utilization after research bronchoscopy
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P702
VO 44
IS Suppl 58
A1 Elise Orvedal Leiten
A1 Einar Marius Hjellestad Martinsen
A1 Tomas Mikal Lind Eagan
A1 Per Sigvald Bakke
A1 Ingvild Haaland
A1 Øistein Svanes
A1 Gunnar Reksten Husebø
A1 Rune Grønseth
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P702.abstract
AB Background and aims: Based on a study on airways inflammation and the respiratory microbiome, we aimed to investigate if bronchoscopy leads to fever, healthcare utilization or hospitalization in obstructive lung disease and control subjects.Methods: From the ongoing Bergen Airways Microbiome Study 39 COPD patients (FEV1 ≥ 17% of predicted values), 2 with asthma, and 33 controls were interviewed 1 week after bronchoscopy regarding fever and healthcare utilization (hospitalization, unscheduled visits to a doctor, antibiotic use). Bronchoscopy included collected protected specimen brushes in both lungs, and bronchoalveolar lavage (BAL) of the right middle lobe in all but 7 subjects. 50 subjects received conscious sedation with alfentanil. 24 subjects received only topical lidocaine.Results: 31 women and 43 men, aged 35 to 81 years were examined. The post bronchoscopy fever rate was 41%, and was not related to healthcare utilization. 7 subjects received unscheduled medical care after the procedure, of these 1 was admitted for a bronchospasm (1 day), 2 for pneumonia (1 and 2 days), and one for 3 days for an unverified cerebral vascular incident. Case/control-status, sex, age, smoke, FEV1% of predicted, arterial PaO2, BAL yield, and conscious sedation were not associated with fever or healthcare utilization. A combination of low FEV1, exacerbation history and high symptom score did not predict outcomes in a logistic regression model.Conclusion: Fever was a frequently reported side effect of bronchoscopy, but was not related to need of healthcare attention. Neither case/control status nor FEV1 was related to healthcare utilization. Research bronchoscopy is safe in COPD, even with very low lung function.