TY - JOUR T1 - Impulse oscillometry measurements are correlated to quality of life in patients with pulmonary sarcoidosis JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P740 AU - Konstantinos Karagiannis AU - Andras Bikov AU - Martina Bonifazi AU - Harpal Kalsi AU - Harpreet Lota AU - Sally Meah AU - Peter Barnes AU - Athol U. Wells AU - Paolo Paredi AU - Omar S. Usmani AU - Elisabetta Renzoni Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P740.abstract N2 - RationaleAlthough airway involvement is prevalent in pulmonary Sarcoidosis, its impact on quality of life is unclear. Impulse Oscillometry (IOS) measurements may display higher sensitivity than FEV1 and other conventional markers of airway obstruction. The present study aims to explore the utility of IOS in pulmonary sarcoidosis.Methods63 patients with pulmonary sarcoidosis were recruited from our Sarcoid clinic. IOS and lung function tests were performed by every subject on the same day, and all participants completed Leicester's Cough (LCQ) and St George's Respiratory Questionnaires (SGRQ). Correlations between IOS and questionnaire scores were measured by Spearman's rho.ResultsDemographics are shown in table 1View this table:DemographicsThere were significant correlations between IOS measurements (R5, X5, Fres, AX) with lung volumes (FEV1%, FVC%, RV/TLC) and maximal expiratory flows (MEF75,50,25%). R5, X5, Fres, AX were more tightly linked to the total SGRQ scores (rho=0.41, -0.43, 0.38, 0.44, respectively, p<0.01) than lung function tests (rho=0.28,p=0.03 for both FVC% and RV/TLC, no significant correlation with FVE1, MEF25/50/75 and DLCO). LCQ score was correlated with the difference R5-R20 (rho=-0.32,p=0.01).ConclusionIOS measurements correlate with symptom burden more strongly than conventional lung function markers in sarcoidosis. Whether this reflects their higher sensitivity to small airway changes requires further study. ER -