PT  - JOURNAL ARTICLE
AU  - Belaconi, Ionela
AU  - Toma, Claudia
AU  - Stancu, Simona
AU  - Dumitrache-Rujinski, Stefan
AU  - Tudose, Cornelia
AU  - Croitoru, Alina
AU  - Grigoriu, Liliana
AU  - Leonte, Diana
AU  - Magheran, Elena
AU  - Bogdan, Miron
TI  - ANCA associated vasculitis – Evaluation of diagnosis, treatment and outcome in a group of 68 patients
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P4515
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P4515.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P4515.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Background: Granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA) and microscopic polyangiitis(MPA) are antineutrophil cytoplasmic antibodies (ANCA) – associated vasculitides with significant morbidity and mortality.Objective: We evaluated the evolution of 68 patients diagnosed with vasculitis between 1997 and 2013, treated with conventional treatment (prednisolone and pulse cyclophosphamide initially, and after remission with prednisolone and azathioprine).Results: We evaluated 68 patients (36 females), median age of 54 years (range 17-84), with a median duration of follow up of 39.5 months (range 1-144 months), 26 with GPA, 40 with MPA and 2 with EGPA. Seven patients out of 13 performed had alveolar haemorrhage at broncho-alveolar lavage. Seventeen patients had relapses (25%), 1 developed subglottic stenosis, 1 retro-orbital pseudo tumor and 2 patients developed opportunistic infectious of the lung cavities and needed lung resection. Due to immunosuppressive therapy 2 patients developed lung tuberculosis (one multi-drug-resistant) and 1 pulmonary nocardiosis. Patients with GPA had renal failure at diagnosis in a procent of 46,2% and MPA 90%. Twenty seven patients needed definitive hemodialysis for renal failure. Fifteen patients died: 10 with alveolar haemorrhage, 3 with sepsis, 1 with stroke and one cancer. MPA diagnosis, older age and renal failure were predictors of death.Conclusions: Significant differences exist between GPA and MPA at the initial presentation that can predict the evolution of the disease. The management of patients with ANCA-associated vasculitides is difficult and marked by the adverse effects of the therapy.