TY - JOUR T1 - Cognitive dysfunction is greater in patients hospitalised with COPD exacerbations than with worsening heart failure JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P574 AU - Mohani Bajaj AU - Andrew Tappouni AU - Michael Tumilty AU - James Dodd AU - Paul Jones AU - Emma Baker Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P574.abstract N2 - IntroductionPeople with COPD have cognitive dysfunction, which is greater in those hospitalised for exacerbations than in stable outpatients [Dodd et al Chest 144:119-27].AimsWe tested the hypothesis that cognitive dysfunction is a disease-specific feature of COPD exacerbations by comparing cognition in patients hospitalised with COPD exacerbations or with worsening heart failure.MethodsPatients hospitalised with COPD exacerbations or congestive or left sided heart failure (HF) without previous stroke, neurological disease or alcohol dependence completed the Montreal Cognitive Assessment (MoCA), Hospital Anxiety and Depression score (HAD) and underwent spirometry and review of clinical records.ResultsAge, acute illness severity and comorbidities were similar in COPD and HF.View this table:Table 1. Patient characteristicsMoCA was lower in COPD (21.0±5.8) than in HF (24.9±3.6, p=0.013). Visuospatial/executive function (COPD 2.7±1.5; HF 3.9±1.3, p=0.008) and attention (COPD 3.8±1.7; HF 5.0±1.3, p=0.014) were impaired in COPD and anxiety and depression (HAD. COPD 19.6±9.8; HF 13.9±7.5, p=0.045) were increased. On multiple linear regression, HAD (p=0.01), pack years (p=0.033) and age (p=0.008), but not primary diagnosis (COPD/HF) or gender, were independently associated with MoCA.ConclusionsHospitalised COPD patients with exacerbations have greater cognitive impairment than those with worsening heart failure. Differences may be explained by greater smoking load and more anxiety and depression. ER -