TY - JOUR T1 - Quadriceps muscle oxygenation parameters during exercise in ILD patients JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P3687 AU - Shinichi Arizono AU - Hiroyuki Taniguchi AU - Yasuhiro Kondoh AU - Tomoki Kimura AU - Kensuke Kataoka AU - Tomoya Ogawa AU - Fumiko Watanabe AU - Jun Hirasawa AU - Takuro Furukawa AU - Kazuyuki Tabira Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P3687.abstract N2 - Background: Poor exercise capacity was related the impaired quadriceps muscles function in patients with interstitial lung diseases (ILD). In normal subjects, tissue oxygen saturation (StO2) in Quadriceps muscle related exercise capacity. ILD patients have severe hypoxia during exercise. We hypothesized that the SpO2 - StO2 which was considered exercise induced hypoxia would be usefulmuscle oxygenation parameter than the StO2. The purpose of the present study was to compare the SpO2 - StO2 and the StO2 in relation to exercise capacity, pulmonary functional, dyspnea and health status in ILD patients.Methods: Forty ILD patients (%VC: 88.8±19.0%) were measured cardiopulmonary exercise test (CPET), pulmonary functional test (%VC, %DLco), dyspnea (Baseline dyspnea index: BDI), health status (St. George's Respiratory Questionnaire: SGRQ), muscle strength tests. During CPET, we continuously monitored SpO2, and measured StO2 in Quadriceps muscle with continuous-wave near-infrared spectroscopy. We calculated Pearson correlation coefficients to examine the relationships between the StO2, the SpO2 - StO2 and measurements.Results: At the end of CPET, the StO2 was 52.9%, the SpO2 - StO2 was 35.5%. StO2 was significantly correlated only with %DLco (p<0.05). The SpO2 - StO2 was significantly correlated with peakVO2, %VC, %DLco, BDI, SGRQ, and SpO2(p<0.05).Conclusion: In ILD patients, our study showed that the SpO2 - StO2 may be useful muscle oxygenation parameter than the StO2. ER -